EU backs changes to injections to expand monkeypox vaccine supply – zimo News


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European countries can expand their limited monkeypox vaccine stocks by administering smaller doses of the vaccine, the European Medicines Agency (EMA) said on Friday.

The agency’s recommendation is consistent with the so-called fractional-dose approach endorsed by U.S. regulators, in which a single vaccine vial can be used to deliver up to five separate doses — rather than a single dose — by splitting between layers A smaller dose of the vaccine is given. Skin (intradermal injection).

The vaccines, called Jynneos, Imvanex and Imvamune, depending on geographic location, are designed to be injected into a layer of fat under the skin, known as a subcutaneous injection.

Monkeypox: What you need to know about the virus—and how to protect yourself

As an interim measure, national authorities may decide to use the vaccine as an intradermal injection in lower doses to protect those at risk during the current monkeypox outbreak, while vaccine supplies remain limited, the EMA said. .

The recommendation is based on a study of about 500 adults that compared the effects of intradermal or subcutaneous injections with two doses of the vaccine given about a month apart.

Health officials have found that the monkeypox vaccine, given intradermally or in small doses between skin layers, is as effective as traditional methods and allows five people to be vaccinated with a single dose instead of one. Pictured: A Monkepox test tube that tested “positive” in this illustration taken on May 22, 2022.
(Reuters/Dado Ruvic/Illustration)

People who received the intradermal injection received one-fifth the dose subcutaneously, but produced antibody levels similar to those who received the original subcutaneous dose, the EMA said.

However, the agency warns that there is a higher risk of local reactions, such as redness, thickening or discoloration of the skin after intradermal injections.

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Since early May, more than 40,000 confirmed cases of monkeypox, including a handful of deaths, have been reported in more than 80 countries where the virus is not endemic.

The World Health Organization has declared the outbreak a global health emergency. The vaccine, made by Bavarian Nordic, is now out of stock.

Some countries are expanding available doses with unknown results to make the most of existing supplies.

The UK, Canada and Germany each receive one dose of the vaccine instead of two, allowing them to vaccinate more people, even though everyone may have less or less durable protection.

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